Rapamycin and cholesterol

Is there any guidance re. taking Rapa when one has high cholesterol?

Good question @mkpartin . I’m sure @Jake has some info about this.

So when it comes to cholesterol and rapamycin theres data that states that by downregulating the expression of PPARgamma, rapamycin can decrease cholesterol accumulation in 3T3-L1 cells and inhibit its leptin-secreting capability. This data provides an explanation for rapamycin-induced hyperlipidemia which is seen commonly in clinical practice involving rapamycin treatment.

My Husband has high cholesterol, he has taken Rapamycin for 15 weeks, recent bloodwork shows a reduction in his cholesterol , no reduction in his triglycerides

Good news at least for his cholesterol!

I’m 67 YO and I am in great health. I exercise 6 days a week and have been on Keto for 5 years so I am very lean. Just had my annual doctor’s checkup and all blood work looks good except my cholesterol numbers have been slowly increasing for a few years so I finally agreed to go on a low dose Statin.

I am ready to start a Rapamycin program. Are there any known bad interactions with Statins?

I think I need a layman’s interpretation of this :slight_smile:

Essentially, rapamycin can increase your cholesterol.

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I thought this was interesting

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That’s not automatically a bad thing, correct?

[[Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review]. (https://Since elderly people with high LDL-C live as long or longer than those with low LDL-C, our analysis provides reason to question the validity of the cholesterol hypothesis)]

(Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review)

I started taking Rapamycin a while back and I also take statins.

The only problem I saw is that my liver enzymes went up right after taking Rapamycin. I don’t know if this raise in enzymes is a problem or it’s a temporary elevation. (They went down again after a few days).

The doctor, however, asked me to stop Rapamycin due to potential risks to the liver …

Any thoughts?

Mine initially went up slightly but returned to normal and hasn’t returned


So now, even right after taking Rapamycin, your liver enzymes remain low?

(I just checked once)

my last 2 blood tests were 5 days after taking rapamycin, I normally take my rapamycin on Mondays and always take blood tests on Saturdays. This routine works for schedule. But to your question, my liver enzymes were not elevated.

I already have High cholestrol. Nothing has brought it down. If it goes up on this med I may have to stop taking it

I’d advise anyone and everyone here who has been told they have “high” cholesterol and to go on a statin, to start learning more about the established and well-documented dogmatic view, e.g. the lipid hypothesis. Good follows on Twitter would be Dave Feldman, David Diamond, and Marion Holmann, for starters. Do your own research/reading. Make up your own opinions on what you learn. It might not come as a total shock to you that you might learn what we’ve been told about the dangers of “high” cholesterol are largely fabricated exaggerations (lies) intended to keep lots of profits in the hands of pharma. Certainly, much more to learn, that’s for sure.

My cholestrol has gone up since taking this