Rapamycin and A1C

Does anyone have any research on how rapamycin may effect glucose tolerance and A1C. I have been taking 5-6MG 1 x week for 8 months (not cycling off) and in my latest bloodwork for the first time my A1C came in at 5.8, so just above normal and in the “pre-diabetes” category. I believe I read somewhere that over a prolonged period of time that rapamycin was found to create glucose intolerance in mice. I am going to take the next 4 weeks off and then go on a 2 ,month on 1 month off to see if the A1c normalizes. Anyone have any guidance or thoughts?

Thanks for posting this. The news is concerning. But I think it would be helpful if you could post other results you’ve got from the same test going back a ways. Do you have those available? Very helpful to know how much of an outlier this new value is in your own history.

Thanks for responding. Had my records pulled and in 2022 A1C was 5.5 and in 2021 was also 5.5. So not as significant an increase as I thought and may have nothing to do with Rapamycin and may be diet related.

I have been taking Rapamycin for 2 years and my A1C as measured last week was 4.8. I have not seen an uptick in my A1C as of yet,

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Hi- This is Shriya from the Healthspan Clinical Team! Elevated blood sugar does sometimes occur on the rapamycin protocol. Rapamycin lowers insulin secretions which is a positive in the context of overall longevity. We’ve noted that elevated doses of Rapamycin can precipitate hyperglycemia as a consequence of diminished insulin secretion. When such reduced insulin levels coincide with a diet rich in carbohydrates, a form of hyperglycemia could possibly emerge in certain individuals. From a lifestyle perspective, a modification involving a decrease in the consumption of simple carbohydrates can help reduce these levels. For some specific cases, the introduction of metformin into the treatment regimen could be a viable strategy for the regulation of these levels. Lastly, there is no harm at all in reducing the frequency of your dosing schedule, so that is something we can implement. If you have concerns about your A1C levels as shown on blood tests, we recommend reaching out to our healthcare team so that we can develop a personalized solution!

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