So ultimately the inhibition of mTOR for its therapeutic benefits is less than 48 hours. To the extent that you are dampening protein synthesis, it is for a transient period of time. What we tell patients is if you are concerned about muscle gains derived from resistance training, just take the rapamycin on a non-lifting day. The other aspect is how much are you dampening? When we do a transcriptional analysis of rapamycin patients they exhibited optimal longevity and skeletal muscle transcription expression. There’s also a well reviewed analysis of how rapamycin protects against age-related muscle loss Rapamycin protects aging muscle - PMC
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What is so interesting about the way that Rapamycin inhibits mTOR is that it actually prevents sarcopenia. And guys in other forums consistently said that they actually gain more strength.
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Welcome to the board @Chuckfrasher
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Yes, Dr. Blagosklonny has been very adamant that muscle growth and rapamycin and intermittent mTOR inhibition are not at odds with each other.
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Thanks Jeff. 
it’s a pleasure to be here.