My exercise routine has not changed, however I have noticed a marked improvement in my stamina. Cardiovascular activities that would’ve left me “winded” before barely affect me now. I’ve not made any other changes other than oral Rapamycin for 3 months.
Hello!
This is Brandon from the Clinical Team. Thank you for sharing your experience, and that is so exciting to hear you are noticing such improvements in stamina. While I would assume most do not view taking rapamycin through this lens - the mechanism certainly exists and does logically make sense. I myself participate in triathlons and reap similar benefits with my longer runs and bike rides, so it is nice to hear someone else also enjoy this benefit!
Low-dose rapamycin may benefit stamina and cardiovascular performance through its targeting of the mTOR (mechanistic target of rapamycin) pathway, which regulates cellular energy, metabolism, and recovery. By modulating mTOR activity, rapamycin helps improve mitochondrial function, reduce oxidative stress, and enhance endurance. Additionally, it should lower inflammation and support cardiovascular health by improving vascular function and reducing arterial stiffness. These effects collectively contribute to better physical performance and stamina, particularly in age-related contexts where mTOR dysregulation often impairs these functions.
By inhibiting mTOR, rapamycin enhances mitophagy, the process of clearing damaged mitochondria, and promotes mitochondrial biogenesis, the generation of new, functional mitochondria. This helps maintain mitochondrial quality and energy efficiency. As mentioned above, rapamycin reduces oxidative stress and inflammation, which are critical factors in mitochondrial dysfunction. These effects collectively contribute to improved mitochondrial performance, resilience to age-related decline, and overall cellular health.
See you out there! 