Gerostasis mechanisms and possible results: an exploration

Dasatinib synergized with Rapamycin has been published to have a more effective result in inhibiting Src/PI3K/Akt/mTOR

Q: what might be the possibility of Disrupting the Signaling Cascade: Dasatinib, Rapamycin, and Aging

  • Src/PI3K/Akt/mTOR: This complex cellular signaling pathway regulates cell growth, proliferation, and survival. Increased activity in this pathway is associated with aging and some cancers.
  • Dasatinib: A drug that inhibits Src, a protein upstream in the signaling cascade.
  • Rapamycin: A drug that inhibits mTOR, a protein downstream in the cascade.

The Strategy:

Let’s open the conversation of combining Dasatinib and Rapamycin to target the Src/PI3K/Akt/mTOR pathway at multiple points, potentially enhancing its inhibition. This could theoretically lead to various changes in an older person’s well-being.

Possible Day-to-Day Changes:

  • Improved Energy Levels: The pathway regulates cellular metabolism. Inhibition might lead to more efficient energy production, resulting in increased stamina and reduced fatigue, a common complaint among older adults.
  • Enhanced Muscle Function: The pathway is involved in muscle protein synthesis. Inhibition could promote muscle growth and repair, potentially improving strength and balance, which can decline with age.
  • Sharper Cognitive Function: The pathway is linked to cognitive processes like learning and memory. Inhibition could improve focus, mental clarity, and overall cognitive performance, which can deteriorate with age-related neurodegeneration.
  • Reduced Inflammation: Chronic inflammation is a hallmark of aging and contributes to various ailments. The pathway plays a role in inflammation. Inhibition could lead to a decrease in inflammatory markers, potentially easing aches, pains, and stiffness commonly experienced by older adults.


  • Mr. Jones, 72, might find himself tackling his yard work with more vigor after taking this combination therapy. He might also notice it’s easier to climb stairs and carry groceries.
  • Ms. Smith, 68, might regain some of her memory sharpness, having fewer issues recalling names and remembering appointments. She might also experience a clearer thought process.

Important Considerations:

  • This is a hypothetical scenario.
  • There could be unintended side effects that need careful evaluation.
  • A holistic approach to aging is still vital. This strategy might be a piece of the puzzle, but maintaining a healthy lifestyle with proper diet, exercise, and sleep would remain crucial.