Just wondering if there were any anecdotal reports of recommended peptides to add or avoid during a protocol using Rapamycin and/or Metformin… may the best answers get extra smiley faces!
Hi, this is Shriya from the Clinical Team. As of now, we do not recommend any specific peptides, and there is not much research on interactions between peptides and rapamycin. If you have specific questions about your specific protocols and peptides you are interested in taking, I recommend messaging in our patient portal so that our clinical team can review your specific case.
I’m already experimenting with CJC-1295, BPC-157, and NAD+. I tried combining the NAD+ with anything else but it’s so unstable, it’s not a good idea. Im working heavily with -BPC-157 combined with Adipotide (FTPP) 10mg, but the best results after heavy workouts has been the first 2 mentioned with occasional NAD+.
The rest of the list I would love comment on, which I’m experimenting with, are as follows:
Tesamorelin 5mg
Semaglutide (GLP-1 Analogue)
Epithalon (Epitalon) 50mg
Kisspeptin-10
Sermorelin, GHRP-6, GHRP-2 9mg
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Are you having good results with the BPC157? I am considering trying it for running injuries. I am currently doing a combo for athletic performance and recovery - Ipamorelin, Pinealon, CIC-1295, Pentadeca, Arginate, Thymalin. Too soon to tell for me. ~2 weeks. I also want to try Tesamorelin. Curious about any contraindications around my weekly rapa cycling.
Hello! This is Brandon from the Clinical Team, thanks for posting your thoughts!
While we don’t specialize in the peptide world, I wanted to offer a few ideas about this as it pertains to rapamycin and Metformin. The potential interaction of BPC-157, tesamorelin, and low-dose rapamycin may synergize in supporting tissue repair, metabolism, and anti-aging effects - which seems like your primary health goal with recovery from running.
BPC-157 promotes healing and reduces inflammation by upregulating growth factors and protecting mitochondrial function. This may complement rapamycin’s effects on cellular repair and resilience since rapamycin does play a key role in mitophagy and cellular senescence. I would also expect these desirable outcomes to be further amplified through UCP1 (Uncoupling Protein 1), which is a mitochondrial protein crucial for thermogenesis, especially in brown adipose tissue. It uncouples oxidative phosphorylation by dissipating the proton gradient, releasing energy as heat instead of generating ATP. This process reduces oxidative stress, enhances metabolic flexibility, and supports overall mitochondrial health. By regulating energy expenditure and protecting against mitochondrial dysfunction, UCP1 is linked to improved metabolic health, resilience to obesity, and age-related metabolic decline. Supporting UCP1 activity benefits mitochondrial efficiency and systemic energy metabolism which should then enhance your ability to recover.
We know that rapamycin inhibits mTORC1 and mTORC2. mTORC1 is more involved in things like growth or anabolism. Tesamorelin, a growth hormone-releasing hormone analog, enhances fat metabolism and supports muscle health, potentially counterbalancing rapamycin’s catabolic tendencies on protein synthesis.
Together, these agents might optimize energy, recovery, and repair while mitigating side effects through complementary mechanisms. It is a bit like using testosterone and rapamycin. From the 30,000 foot view, one promotes growth and one inhibits it. Yes, anabolism and catabolism are constantly occurring throughout the body, so this might be a call to action for cycling rapamuycin (i.e., maybe something >7 days, possibly even seasonally based on your training schedule), monitoring biomarkers, and probably analyzing Peak and Trough levels to be sure your dosing is correct.
I hope this is a little bit helpful!