One of the concerns I have is that mTor is a central regulator of spermatogenesis. Emerging Role for Mammalian Target of Rapamycin in Male Fertility - PMC
mTOR plays an important role in male fertility by integrating and mediating signals throughout the male reproductive system. It acts as a central regulator of spermatogenesis.
mTOR inhibitors like rapamycin have been shown to cause reversible infertility in men by reducing testosterone production and sperm counts.
mTORC1 and mTORC2 are expressed in germ cells and somatic cells of the testes, and each play distinct roles in regulating spermatogenesis.
mTORC1 is involved in Sertoli cell proliferation, metabolism, and redox balance, which impacts their ability to support germ cell development.
mTORC2 regulates the blood-testis barrier dynamics that allow preleptotene spermatocytes to enter the adluminal compartment for meiosis.
mTOR mediates the transcriptional and translational control of genes required for spermatogenesis at different stages.
Inhibition of mTORC1 blocks spermatogonial differentiation and entry into meiosis, suggesting it is required for germ cell development.
Dysregulation of mTOR signaling has been linked to defects in Sertoli cell polarity, germ cell apoptosis, and male infertility.
Targeting specific mTOR complexes may offer potential therapies for male fertility or male contraceptives.
Further research is needed to fully understand the distinct roles of mTORC1 and mTORC2 in the male reproductive system.
Any thoughts about this? Or a protocol that addresses this?