Rapamycin prolongs the beneficial effects of Ketamine

A 2020 study showed that “rapamycin prolonged the antidepressant effects of ketamine, and increased the response and remission rates at 2 weeks following treatment.” [Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin]

Does anyone have experience taking rapamycin, along with ketamine?

(Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin | Neuropsychopharmacology)

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We currently don’t have any patients who have supplemented ketamine therapy with rapamycin. However, we’re going to do an analysis and reach out to the authors to get more information.

Thank you for posting this topic to the forum. Look out for updates once we have done our analysis.


For more information: Dr. John Krystal is the Robert L. McNeil, Jr., Professor of Translational Research; Professor of Psychiatry, Neuroscience, and Psychology; Chair of the Department of Psychiatry at Yale University; and Chief of Psychiatry and Behavioral Health at Yale-New Haven Hospital.

Dr. Krystal is a leading expert in the areas of alcoholism, post-traumatic stress disorder, schizophrenia, and depression. His work links psychopharmacology, neuroimaging, molecular genetics, and computational neuroscience to study the neurobiology and treatment of these disorders.

He is best known for leading the discovery of the rapid antidepressant effects of ketamine in depressed patients.

[Ketamine + Rapamycin: Optimizing Ketamine’s Antidepressant Effects]. (Ketamine + Rapamycin: Optimizing Ketamine's Antidepressant Effects - YouTube)

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