# I am currently trying to gain muscle mass. Will taking Rapamycin blunt it? **URL:** \ **Category:** Rapamycin\ **Created:** [September 22, 2022, 6:55pm UTC](https://community.gethealthspan.com/t/i-am-currently-trying-to-gain-muscle-mass-will-taking-rapamycin-blunt-it/28 "2022-09-22T18:55:05Z")\ **Posts on this page:** 5\ **Page:** 1
**Author:** ![Jake](https://yyz2.discourse-cdn.com/flex036/user_avatar/community.gethealthspan.com/jake/32/24_2.png) [@Jake](https://community.gethealthspan.com/u/Jake)\ **Post date:** [September 22, 2022, 6:55pm UTC](https://community.gethealthspan.com/t/i-am-currently-trying-to-gain-muscle-mass-will-taking-rapamycin-blunt-it/28/1 "2022-09-22T18:55:05Z")
So ultimately the inhibition of mTOR for its therapeutic benefits is less than 48 hours. To the extent that you are dampening protein synthesis, it is for a transient period of time. What we tell patients is if you are concerned about muscle gains derived from resistance training, just take the rapamycin on a non-lifting day. The other aspect is how much are you dampening? When we do a transcriptional analysis of rapamycin patients they exhibited optimal longevity and skeletal muscle transcription expression. There’s also a well reviewed analysis of how rapamycin protects against age-related muscle loss [Rapamycin protects aging muscle - PMC](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738401/) ---
**Author:** ![Chuckfrasher](https://avatars.discourse-cdn.com/v4/letter/c/a9a28c/32.png) [@Chuckfrasher](https://community.gethealthspan.com/u/Chuckfrasher)\ **Post date:** [October 18, 2022, 5:48pm UTC](https://community.gethealthspan.com/t/i-am-currently-trying-to-gain-muscle-mass-will-taking-rapamycin-blunt-it/28/2 "2022-10-18T17:48:26Z")
What is so interesting about the way that Rapamycin inhibits mTOR is that it actually prevents sarcopenia. And guys in other forums consistently said that they actually gain more strength. > **[How rapamycin prevents muscle loss and sarcopenia (first draft) - Dr....](https://www.mikhailblagosklonny.com/blog/how-rapamycin-prevents-muscle-loss-and-sarcopenia-first-draft/)** > > The effect of rapamycin, an anti-aging drug, on the muscle, was puzzling for a decade. It seemed paradoxical that rapamycin, an inhibitor of mTOR component 1 (mTORC1), prevents muscle loss and sarcopenia. Yet, this is well established \[1-5\]. How is... ---
**Author:** ![jeff](https://yyz2.discourse-cdn.com/flex036/user_avatar/community.gethealthspan.com/jeff/32/17_2.png) [@jeff](https://community.gethealthspan.com/u/jeff)\ **Post date:** [October 18, 2022, 8:34pm UTC](https://community.gethealthspan.com/t/i-am-currently-trying-to-gain-muscle-mass-will-taking-rapamycin-blunt-it/28/3 "2022-10-18T20:34:08Z")
Welcome to the board @Chuckfrasher ---
**Author:** ![daniel\_tawfik](https://yyz2.discourse-cdn.com/flex036/user_avatar/community.gethealthspan.com/daniel_tawfik/32/23_2.png) [@daniel\_tawfik](https://community.gethealthspan.com/u/daniel_tawfik)\ **Post date:** [October 18, 2022, 11:24pm UTC](https://community.gethealthspan.com/t/i-am-currently-trying-to-gain-muscle-mass-will-taking-rapamycin-blunt-it/28/4 "2022-10-18T23:24:46Z")
Yes, Dr. Blagosklonny has been very adamant that muscle growth and rapamycin and intermittent mTOR inhibition are not at odds with each other. ---
**Author:** ![Chuckfrasher](https://avatars.discourse-cdn.com/v4/letter/c/a9a28c/32.png) [@Chuckfrasher](https://community.gethealthspan.com/u/Chuckfrasher)\ **Post date:** [October 19, 2022, 11:28pm UTC](https://community.gethealthspan.com/t/i-am-currently-trying-to-gain-muscle-mass-will-taking-rapamycin-blunt-it/28/5 "2022-10-19T23:28:29Z")
Thanks Jeff. 😊🎈it’s a pleasure to be here.