# Fasting and rapamycin

**URL:** <https://community.gethealthspan.com/t/fasting-and-rapamycin/387>\
**Category:** Rapamycin\
**Created:** [May 18, 2023, 10:53am UTC](https://community.gethealthspan.com/t/fasting-and-rapamycin/387 "2023-05-18T10:53:24Z")\
**Posts on this page:** 3\
**Page:** 1

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**Author:** ![Boulderjoe](https://yyz2.discourse-cdn.com/flex036/user_avatar/community.gethealthspan.com/boulderjoe/32/89_2.png) [@Boulderjoe](https://community.gethealthspan.com/u/Boulderjoe)\
**Post date:** [May 18, 2023, 10:53am UTC](https://community.gethealthspan.com/t/fasting-and-rapamycin/387/1 "2023-05-18T10:53:24Z")

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Does anyone here use fasting along with rapamycin? I do a 24 hour fast (breakfast to breakfast) on day 2 of my 7 day cycle with rapamycin.

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**Author:** ![Duncan](https://avatars.discourse-cdn.com/v4/letter/d/ecc23a/32.png) [@Duncan](https://community.gethealthspan.com/u/Duncan)\
**Post date:** [May 24, 2023, 4:31pm UTC](https://community.gethealthspan.com/t/fasting-and-rapamycin/387/2 "2023-05-24T16:31:53Z")

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I do a three-day (72-hour) water fast once per month, usually Thursday evening through Sunday evening. I usually take a rapamycin pulse dose on Sunday mornings. On weekends when I fast, I skip the rapamycin, with the assumption that I already have MTORC1 inhibition from the fasting.

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**Author:** ![Boulderjoe](https://yyz2.discourse-cdn.com/flex036/user_avatar/community.gethealthspan.com/boulderjoe/32/89_2.png) [@Boulderjoe](https://community.gethealthspan.com/u/Boulderjoe)\
**Post date:** [May 24, 2023, 5:06pm UTC](https://community.gethealthspan.com/t/fasting-and-rapamycin/387/3 "2023-05-24T17:06:38Z")

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Thanks. That sounds good. I’m still thinking about what I want to do with fasting.

I wonder what the fasting timeframe is for elevating autophagy. I recall reading it only started after 3-5 days. MTor inhibition would start immediately I assume. Im thinking about using resistance exercise to up regulate mTor in muscles during a fast to minimize muscle loss.