# General **URL:** https://community.gethealthspan.com/c/general/4.md [Latest](https://community.gethealthspan.com/latest.md) · [Categories](https://community.gethealthspan.com/categories.md) · [Tags](https://community.gethealthspan.com/tags.md) --- ## [Welcome to the Healthspan Discussion Board!](https://community.gethealthspan.com/t/welcome-to-the-healthspan-discussion-board/7)
**Author:** [@system](https://community.gethealthspan.com/u/system)\ **Replies:** 16\ **Last updated:** [September 24, 2024, 4:07pm UTC](https://community.gethealthspan.com/t/welcome-to-the-healthspan-discussion-board/7 "2024-09-24T16:07:28Z")
Now that you have joined, we encourage you to take advantage of all the perks this community has to offer. To get started, browse the open discussion topics. If you find a topic of interest, click the topic to join in … --- ## [About the General category](https://community.gethealthspan.com/t/about-the-general-category/3)
**Author:** [@system](https://community.gethealthspan.com/u/system)\ **Replies:** 0
--- ## [Cognitive Decline May Start Years Before You Notice—Here’s Why](https://community.gethealthspan.com/t/cognitive-decline-may-start-years-before-you-notice-here-s-why/2027)
**Author:** [@aman](https://community.gethealthspan.com/u/aman)\ **Replies:** 0\ **Last updated:** [January 21, 2026, 6:50pm UTC](https://community.gethealthspan.com/t/cognitive-decline-may-start-years-before-you-notice-here-s-why/2027 "2026-01-21T18:50:09Z")
Most of us think cognitive decline starts with memory loss, plaques, or neurotransmitter imbalances — but what if the real culprit is an energy crisis inside your neurons? In the latest Beyond Healthspan ep… --- ## [Has anyone been using the new oxytocin product?](https://community.gethealthspan.com/t/has-anyone-been-using-the-new-oxytocin-product/1794)
**Author:** [@AS87](https://community.gethealthspan.com/u/AS87)\ **Replies:** 6\ **Last updated:** [December 13, 2025, 2:12am UTC](https://community.gethealthspan.com/t/has-anyone-been-using-the-new-oxytocin-product/1794 "2025-12-13T02:12:51Z")
curious on how it’s going; experiences, dose timing, etc --- ## [Peptide Semorelin and Rapamycin](https://community.gethealthspan.com/t/peptide-semorelin-and-rapamycin/1760)
**Author:** [@Gregg](https://community.gethealthspan.com/u/Gregg)\ **Replies:** 4\ **Last updated:** [October 23, 2025, 4:05pm UTC](https://community.gethealthspan.com/t/peptide-semorelin-and-rapamycin/1760 "2025-10-23T16:05:04Z")
Hello all, Before taking Rapamycin 9 months ago I was making small but steady strength gains on TRT. That has abruptly ended while taking rapa. I can personally conclude that Rapa negatively influences strength gains … --- ## [Protein & Longevity](https://community.gethealthspan.com/t/protein-longevity/2006)
**Author:** [@daniel\_tawfik](https://community.gethealthspan.com/u/daniel_tawfik)\ **Replies:** 0\ **Last updated:** [October 14, 2025, 2:45am UTC](https://community.gethealthspan.com/t/protein-longevity/2006 "2025-10-14T02:45:54Z")
In this episode of Beyond Healthspan, our clinical research team explores one of the most foundational—and often misunderstood—pillars of healthy aging: protein. Drawing from decades of research in metabolism and gerosc… --- ## [Fourth Phase Water or exclusion-zone (EZ) water and Rapamycin](https://community.gethealthspan.com/t/fourth-phase-water-or-exclusion-zone-ez-water-and-rapamycin/2005)
**Author:** [@charter](https://community.gethealthspan.com/u/charter)\ **Replies:** 1\ **Last updated:** [September 20, 2025, 12:19pm UTC](https://community.gethealthspan.com/t/fourth-phase-water-or-exclusion-zone-ez-water-and-rapamycin/2005 "2025-09-20T12:19:58Z")
Are there any studies on how rapamycin affects EZ water in the body? --- ## [Biological Age Determination](https://community.gethealthspan.com/t/biological-age-determination/2004)
**Author:** [@charter](https://community.gethealthspan.com/u/charter)\ **Replies:** 1\ **Last updated:** [September 16, 2025, 6:25pm UTC](https://community.gethealthspan.com/t/biological-age-determination/2004 "2025-09-16T18:25:32Z")
I am new to this program. Can anyone provide a short summary of how biological age is determined? A few years ago I was told my biological age was lower than my actual age but not by as much as I was told today. .I am … --- ## [Acarbose - feeling full](https://community.gethealthspan.com/t/acarbose-feeling-full/2003)
**Author:** [@Alex](https://community.gethealthspan.com/u/Alex)\ **Replies:** 1\ **Last updated:** [September 11, 2025, 2:11pm UTC](https://community.gethealthspan.com/t/acarbose-feeling-full/2003 "2025-09-11T14:11:11Z")
Is it normal to be feeling full after eating 24 hours after your last dose of acarbose? --- ## [Alzheimer’s Breakthrough? Methylene Blue, Ketones & Light Therapy Explained](https://community.gethealthspan.com/t/alzheimer-s-breakthrough-methylene-blue-ketones-light-therapy-explained/1991)
**Author:** [@daniel\_tawfik](https://community.gethealthspan.com/u/daniel_tawfik)\ **Replies:** 0\ **Last updated:** [August 11, 2025, 11:20pm UTC](https://community.gethealthspan.com/t/alzheimer-s-breakthrough-methylene-blue-ketones-light-therapy-explained/1991 "2025-08-11T23:20:18Z")
Alzheimer’s Breakthrough? Methylene Blue, Ketones & Light Therapy Explained In this episode of Beyond Healthspan, Brandon and Dr. Richard LaFountain examine the work of neuroscientist Dr. Francisco Gonzal… --- ## [Low Dose Methylene Blue... You suggest 5mg as a low dose...how many drops equals 5mg?](https://community.gethealthspan.com/t/low-dose-methylene-blue-you-suggest-5mg-as-a-low-dose-how-many-drops-equals-5mg/1980)
**Author:** [@claudo](https://community.gethealthspan.com/u/claudo)\ **Replies:** 2\ **Last updated:** [July 31, 2025, 4:33pm UTC](https://community.gethealthspan.com/t/low-dose-methylene-blue-you-suggest-5mg-as-a-low-dose-how-many-drops-equals-5mg/1980 "2025-07-31T16:33:27Z")
Continuing the discussion from Low Dose Methylene Blue: You suggest 5mg as a small and proper dosage of Methylene Blue. How many drops equal 5mg?? --- ## [Noob Urolithin-A benefits question](https://community.gethealthspan.com/t/noob-urolithin-a-benefits-question/1757)
**Author:** [@moos](https://community.gethealthspan.com/u/moos)\ **Replies:** 4\ **Last updated:** [July 29, 2025, 9:05pm UTC](https://community.gethealthspan.com/t/noob-urolithin-a-benefits-question/1757 "2025-07-29T21:05:58Z")
Hi. I recently ordered the Healthspan Urolitihin-A. It’s only been a few weeks. I know the research indicates changes after one to two months. Just curious if anyone has been taking it for longer and what effects do … --- ## [Alzheimer's and Rapamycin](https://community.gethealthspan.com/t/alzheimers-and-rapamycin/1976)
**Author:** [@fractalwalker](https://community.gethealthspan.com/u/fractalwalker)\ **Replies:** 0\ **Last updated:** [July 23, 2025, 2:11pm UTC](https://community.gethealthspan.com/t/alzheimers-and-rapamycin/1976 "2025-07-23T14:11:30Z")
Has anyone here been diagnosed with Alzheimers, and has rapamycin helped? --- ## [Low Dose Methylene Blue](https://community.gethealthspan.com/t/low-dose-methylene-blue/1188)
**Author:** [@TankerBoy](https://community.gethealthspan.com/u/TankerBoy)\ **Replies:** 8\ **Last updated:** [July 18, 2025, 6:04pm UTC](https://community.gethealthspan.com/t/low-dose-methylene-blue/1188 "2025-07-18T18:04:58Z")
Anyone here have any experiences taking low dose methylene blue for longevity? --- ## [What Is Metabolic Flexibility? How It Impacts Fat Loss, Energy, and Longevity | Beyond Healthspan](https://community.gethealthspan.com/t/what-is-metabolic-flexibility-how-it-impacts-fat-loss-energy-and-longevity-beyond-healthspan/1970)
**Author:** [@daniel\_tawfik](https://community.gethealthspan.com/u/daniel_tawfik)\ **Replies:** 1\ **Last updated:** [July 18, 2025, 1:16am UTC](https://community.gethealthspan.com/t/what-is-metabolic-flexibility-how-it-impacts-fat-loss-energy-and-longevity-beyond-healthspan/1970 "2025-07-18T01:16:24Z")
What does it really mean to be metabolically flexible? In this episode of Beyond Healthspan, Brandon and Rich unpack one of the most important papers on exercise metabolism and mitochondrial health—coauthor… --- ## [Getting Rapamycin to the UK](https://community.gethealthspan.com/t/getting-rapamycin-to-the-uk/1968)
**Author:** [@Bola](https://community.gethealthspan.com/u/Bola)\ **Replies:** 2\ **Last updated:** [July 18, 2025, 12:06am UTC](https://community.gethealthspan.com/t/getting-rapamycin-to-the-uk/1968 "2025-07-18T00:06:13Z")
Hi, I live in the UK and am interested in getting this medication. How do I go about it? Can it be sent to me? --- ## [Best pairing with Rapamycin? Acarbose vs. SGLT2 vs. both?](https://community.gethealthspan.com/t/best-pairing-with-rapamycin-acarbose-vs-sglt2-vs-both/1938)
**Author:** [@mruniqueid](https://community.gethealthspan.com/u/mruniqueid)\ **Replies:** 3\ **Last updated:** [June 29, 2025, 6:27pm UTC](https://community.gethealthspan.com/t/best-pairing-with-rapamycin-acarbose-vs-sglt2-vs-both/1938 "2025-06-29T18:27:48Z")
I know both Acarbose and SGLT2 inhibitors positively impact metabolic health by reducing the overall glucose burden on the body—each through different mechanisms. When I signed up, I opted for the Rapamycin + Acarbose p… --- ## [Lipid management protocols on Healthspan (ApoB)](https://community.gethealthspan.com/t/lipid-management-protocols-on-healthspan-apob/1928)
**Author:** [@mruniqueid](https://community.gethealthspan.com/u/mruniqueid)\ **Replies:** 4\ **Last updated:** [June 26, 2025, 3:26pm UTC](https://community.gethealthspan.com/t/lipid-management-protocols-on-healthspan-apob/1928 "2025-06-26T15:26:34Z")
I’ve been interested in Rapamycin and Acarbose for a long time (I’m a Peter Attia fan), so I was happy to find Healthspan! Both of those drugs are more targeted at metabolic health by my understanding, but I was wonderin… --- ## [How Stress Alters DNA Methylation to Accelerate Biological Age](https://community.gethealthspan.com/t/how-stress-alters-dna-methylation-to-accelerate-biological-age/1951)
**Author:** [@daniel\_tawfik](https://community.gethealthspan.com/u/daniel_tawfik)\ **Replies:** 0\ **Last updated:** [June 24, 2025, 10:55pm UTC](https://community.gethealthspan.com/t/how-stress-alters-dna-methylation-to-accelerate-biological-age/1951 "2025-06-24T22:55:03Z")
While chronological age (the number of years since birth) is easy to measure, it tells us very little about an individual’s true physiological condition. In contrast to chronological age (years of age since birth), bio… --- ## [The Neuroprotective Properties of Ketones](https://community.gethealthspan.com/t/the-neuroprotective-properties-of-ketones/1934)
**Author:** [@daniel\_tawfik](https://community.gethealthspan.com/u/daniel_tawfik)\ **Replies:** 2\ **Last updated:** [June 14, 2025, 12:59pm UTC](https://community.gethealthspan.com/t/the-neuroprotective-properties-of-ketones/1934 "2025-06-14T12:59:16Z")
This week, we did a deep dive on the neuroprotective properties of ketones. Beta-hydroxybutyrate (BHB) and acetoacetate (AcAc) support brain health through a combination of metabolic, anti-inflammatory, antioxidant, an… --- ## [From Dr. Matt Kaeberlein's talk at the NUS Gerophysics conference](https://community.gethealthspan.com/t/from-dr-matt-kaeberleins-talk-at-the-nus-gerophysics-conference/1935)
**Author:** [@daniel\_tawfik](https://community.gethealthspan.com/u/daniel_tawfik)\ **Replies:** 0\ **Last updated:** [June 9, 2025, 6:57pm UTC](https://community.gethealthspan.com/t/from-dr-matt-kaeberleins-talk-at-the-nus-gerophysics-conference/1935 "2025-06-09T18:57:22Z")
https://x.com/mkaeberlein/status/1932100492458602668 --- ## [The Endocrine Functions of Subcutaneous Fat—And How to Train It](https://community.gethealthspan.com/t/the-endocrine-functions-of-subcutaneous-fat-and-how-to-train-it/1926)
**Author:** [@daniel\_tawfik](https://community.gethealthspan.com/u/daniel_tawfik)\ **Replies:** 0\ **Last updated:** [June 2, 2025, 11:00pm UTC](https://community.gethealthspan.com/t/the-endocrine-functions-of-subcutaneous-fat-and-how-to-train-it/1926 "2025-06-02T23:00:39Z")
Dr. LaFountain interviews Dr. Aaron Slusher on the endocrine dynamics of subcutaneous fat. This episode is based on Dr. Slusher’s recent research review, where he explores how abdominal subcutaneous fat (Ab… --- ## [SGLT2 Inhibition by Enavogliflozin Significantly Reduces Aβ Pathology and Restores Cognitive Function via Upregulation of Microglial AMPK Signaling in 5XFAD Mouse Model of Alzheimer's Disease](https://community.gethealthspan.com/t/sglt2-inhibition-by-enavogliflozin-significantly-reduces-a-pathology-and-restores-cognitive-function-via-upregulation-of-microglial-ampk-signaling-in-5xfad-mouse-model-of-alzheimers-disease/1925)
**Author:** [@daniel\_tawfik](https://community.gethealthspan.com/u/daniel_tawfik)\ **Replies:** 0\ **Last updated:** [June 2, 2025, 10:40pm UTC](https://community.gethealthspan.com/t/sglt2-inhibition-by-enavogliflozin-significantly-reduces-a-pathology-and-restores-cognitive-function-via-upregulation-of-microglial-ampk-signaling-in-5xfad-mouse-model-of-alzheimers-disease/1925 "2025-06-02T22:40:12Z")
https://onlinelibrary.wiley.com/doi/10.1111/acel.70101 A recent study published in Aging Cell explores this possibility using Enavogliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor. The study examines wheth… --- ## [Fungal mouth infection](https://community.gethealthspan.com/t/fungal-mouth-infection/1922)
**Author:** [@Draus](https://community.gethealthspan.com/u/Draus)\ **Replies:** 1\ **Last updated:** [May 29, 2025, 2:08pm UTC](https://community.gethealthspan.com/t/fungal-mouth-infection/1922 "2025-05-29T14:08:49Z")
Im just looking for some common sense advice. I had developed a funhal infection prior to starting Rapamiacin, but thought it was cleared up prior to taking my first anf only dose. I had been taking Clotrimazol and was p… --- ## [The Hidden Ways Sugar Accelerates Aging – My Perspective from the Fox News Interview](https://community.gethealthspan.com/t/the-hidden-ways-sugar-accelerates-aging-my-perspective-from-the-fox-news-interview/1920)
**Author:** [@daniel\_tawfik](https://community.gethealthspan.com/u/daniel_tawfik)\ **Replies:** 0\ **Last updated:** [May 28, 2025, 10:10pm UTC](https://community.gethealthspan.com/t/the-hidden-ways-sugar-accelerates-aging-my-perspective-from-the-fox-news-interview/1920 "2025-05-28T22:10:05Z")
Earlier this month, I had the opportunity to speak with Fox News Digital about how sugar impacts aging in ways that go far beyond weight gain. I’ve spent the past several years focused on bridging the gap between emerg… --- ## [How Endogenous Fructose Fuels Inflammation and Accelerates Aging](https://community.gethealthspan.com/t/how-endogenous-fructose-fuels-inflammation-and-accelerates-aging/1899)
**Author:** [@daniel\_tawfik](https://community.gethealthspan.com/u/daniel_tawfik)\ **Replies:** 0\ **Last updated:** [May 9, 2025, 12:05am UTC](https://community.gethealthspan.com/t/how-endogenous-fructose-fuels-inflammation-and-accelerates-aging/1899 "2025-05-09T00:05:45Z")
Brandon Fell and Dr. Rich LaFountaine from the Healthspan Med research team did a deep take a deeper dive into the surprising ways fructose impacts your health, even when you’re not eating it. That’s right!… --- ## [Mitochondrial Mechanisms Driving Neuroprotective and Cognitive Benefits](https://community.gethealthspan.com/t/mitochondrial-mechanisms-driving-neuroprotective-and-cognitive-benefits/1895)
**Author:** [@daniel\_tawfik](https://community.gethealthspan.com/u/daniel_tawfik)\ **Replies:** 0\ **Last updated:** [May 4, 2025, 7:04pm UTC](https://community.gethealthspan.com/t/mitochondrial-mechanisms-driving-neuroprotective-and-cognitive-benefits/1895 "2025-05-04T19:04:54Z")
We outlined the mechanisms behind the neuroprotective benefits of methylene blue. --- ## [Promoting health and survival through lowered body temperature](https://community.gethealthspan.com/t/promoting-health-and-survival-through-lowered-body-temperature/1893)
**Author:** [@daniel\_tawfik](https://community.gethealthspan.com/u/daniel_tawfik)\ **Replies:** 0\ **Last updated:** [May 2, 2025, 4:01pm UTC](https://community.gethealthspan.com/t/promoting-health-and-survival-through-lowered-body-temperature/1893 "2025-05-02T16:01:39Z")
https://www.nature.com/articles/s43587-025-00850-0 Bruno Conti and Rafael de Cabo discuss the mechanisms by which lowered body temperature prolongs lifespan and contributes to the effects of calorie restriction --- ## [NYTimes: Can Metformin Actually Slow the Aging Process?](https://community.gethealthspan.com/t/nytimes-can-metformin-actually-slow-the-aging-process/1892)
**Author:** [@daniel\_tawfik](https://community.gethealthspan.com/u/daniel_tawfik)\ **Replies:** 0\ **Last updated:** [May 1, 2025, 4:55pm UTC](https://community.gethealthspan.com/t/nytimes-can-metformin-actually-slow-the-aging-process/1892 "2025-05-01T16:55:47Z")
https://www.nytimes.com/2025/05/01/well/metformin-aging-longevity-benefits-risks.html Prompted by the growing off-label use of geroprotective drugs, a new New York Times feature examines metformin’s candidacy as an “ant… --- ## [What’s the Optimal Dose of Methylene Blue for Depression?](https://community.gethealthspan.com/t/what-s-the-optimal-dose-of-methylene-blue-for-depression/1891)
**Author:** [@daniel\_tawfik](https://community.gethealthspan.com/u/daniel_tawfik)\ **Replies:** 0\ **Last updated:** [April 30, 2025, 2:47am UTC](https://community.gethealthspan.com/t/what-s-the-optimal-dose-of-methylene-blue-for-depression/1891 "2025-04-30T02:47:25Z")
In response to a patient inquiry, Dr. Richard LaFountain provides an overview of the current evidence surrounding methylene blue dosing protocols for the adjunctive treatment of depression. The article summarizes key fin… [Next page](https://community.gethealthspan.com/c/general/4.md?page=1)